Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India

Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India

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Abstract Background Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms.Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasma cell dyscrasias.They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary Extramedullary Plasmacytoma (SEP) and multiple solitary plasmacytomas (MSP).In this study, we discuss the clinical, histopathological and immunohistochemical characteristics of solitary plasmacytomas.

Methods A 13 year retrospective analysis of solitary plasmacytomas was performed from a Eye Patch single tertiary care center.Bone marrow evaluation was done concurrently at the time of diagnosis to rule out the presence of multiple myeloma.Results A total of 29 cases fulfilled the diagnostic criteria for SP during the study period.SPB accounted for 55.

2%, SEP for 44.4% and MSP for 3.4% of the cases.The most common sites involved were the paranasal sinuses and vertebrae.

Other infrequent sites included lymph node, tonsil Nesting Equipment and lungs.The mean age of presentation of SPB was a decade later than SEP.A male preponderance was observed in both subtypes.Conclusion Solitary plasmacytoma is a rare entity, the diagnosis of which requires a systematic approach.

There is limited data available in the literature on the clinico-pathological characteristics of SP from India.